Strand Separation

• oriC:

  • 245 bp
  • 9-13bp repeated sequence (9mers and 13mers)

• Helicases: unwind DNA, break hydrogen bonds

  • DnaA (protein) (gene dnaA)
    • initiator protein
    • binds oriC
    • promotes double-helix opening
    • DnaB loading

ATP Hydrolysis

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