Acid-Base Properties

• pK of a chemical group is the pH at which the group is half ionized.

• pK1 = ? - carboxylic acid (pK ~2.2)

  • Above pH 3.5 entirely in carboxylate form

• pK2 = ? - amino groups, (pK ~9.4)

  • Below pH 8.0 in ammonium ion form

• pKR = side groups with acid-base properties

pK1

pK2

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