Many Enzymes Occur in Multiple Forms
Isoenzymes or Isozymes
- catalyze same reaction
- differ in kinetic properties
- differ in response to allosteric modulators
Distribution of isozymes reflects at least four factors.
- differing metabolic patterns in different organs
- different locations & metabolic roles of a given enzyme within one type of cell
- differentiation & development of adult tissues from their embryonic or fetal forms
- fine tuning of metabolic rates through different responses of isozyme forms to allosteric modulators.