Thiamine (Vitamin B1)

• Thiamine Pyrophosphate (TPP)

• Promotes decarboxylation of a-keto acids & the cleavage of a-hydroxyketones

• Beriberi

  • neurological disorders
  • paralysis
  • weight loss

• Enzymes

  • pyruvate decarboxylase
    • fermentation of glucose to alcohol in yeast
  • pyruvate dehydrogenase
    • pyruvate to acetyl-CoA
  • a-ketoglutarate dehydrogenase
    • a-ketoglutarate to succinyl-CoA

Previous slide

Next slide

Back to first slide

View graphic version