Oncogenes and Cancer

5/4/00

Click here to start

Table of Contents

Oncogenes and Cancer

Defined Life Span of Organisms

Defined Life Span of Organisms

Established Cell Lines

Established Cell Lines

Multiple Genetic Changes

Tumor Causing Virus

Transforming Viruses Carry Oncogenes

Transforming Viruses Carry Oncogenes

Cellular Response to Infection

Cellular Response to Infection

Examples of Viral Oncogenes

Transforming Retrovirus

Transforming Retrovirus

A closer look at retroviral oncogenes and their cellular counterparts

Two theories on why the different properties of v-onc & c-onc

Two theories on why the different properties of v-onc and c-onc

How closely related are v-onc and c-onc genes?

How closely related are v-onc and c-onc genes?

Ras proto-oncogenes can be activated by mutation

Ras proto-oncogenes can be activated by mutation

Insertion, Translocation, or Amplification

Insertions of Avian Leukemia Virus (ALV) at c-myc locus occur at various positions, and activate the gene in different ways.

Insertions of Avian Leukemia Virus (ALV) at c-myc locus occur at various positions, and activate the gene in different ways.

Insertions of Avian Leukemia Virus (ALV) at c-myc locus occur at various positions, and activate the gene in different ways.

Oncogenes code for components of signal transduction cascades

Oncogenes code for components of signal transduction cascades

Oncogenes code for components of signal transduction cascades

Growth Factor Receptor Kinases & Cytoplasmic Tyrosine Kinase

Oncoproteins as Transcription Factors

RB is a tumor suppressor that controls the cell cycle

p53 Suppresses Growth and Triggers Apoptosis

p53 Suppresses Growth and Triggers Apoptosis

p53 Suppresses Growth and Triggers Apoptosis

Author: Laura K. Thompson