Translocations

• Reciprocal Translocation

  • B lymphocytes
    • Chromosome 8: c-myc
    • Chromosome 14: IgH
  • T lymphocytes
    • Chromosome 8: c-myc
    • Chromosome14 (TcRa) or Chromosome 7 (TcRb)

• Translocation activates c-myc genes

  • new region with active Ig or TcR gene?
  • c-myc structure may be changed?

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