PPT Slide

EGR or PDGF

EGF

Receptor

Ras-Independent

Events

Tyrosine

Phosphorylation

Serine/Threonine

Phosphorylation

Serine

Phosphorylation

Threonine/Tyrosine

Phosphorylation

MAP Kinases

(ERK1 & ERK2

Cytoplasm

Nucleus

Extracellular

MEK

(MAP Kinase

Kinase)

Grb2 = adaptor protein

SOS = guanine nucleotide release factor

Raf = farnyesylated Ras

Ras = oncoprotein (rat sarcoma)

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