Collagen: A Triple Helical Cable

• Amino Acid Composition: 33% Gly; 15-30% Pro & 4-hydroxyproline (Hyp).

• Helices parallel

  • right-handed helix
  • ropelike twist to form a triple-helical structure
  • every third residue is gly: passes through center of the helix

• Covalently attached carbohydrates

  • 5-hydroxylysine

• Human Diseases

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