Translation In Eukaryotes
Initiation Factors:
- CBP: cap binding protein (eIF-4 in mammals)
- eIF4-A binds 5’cap and unwinds mRNA at 5’end
- eIF4-B assists further unwinding downstream
- eIF2-GTP: 3 subunits abg
- Assists aminoacyl-tRNA binding
- eIF3: needed to maintain free 40S & binding of eIF-2-GTP + amino acyl-tRNA
- eIF-6: also needed to maintain free 40S
- eIF5: GTPase, needed for 60S joining, & release of eIF-2 & eIF-3