Biology 221-01: Genetics

Summer II - 2017

Dr. Wade Worthen, TNS 171B
wade.worthen@furman.edu
Phone: 294-3390
Office Hrs: by appt

Lecture: 1:30 - 3:30 M, W, TH, Townes South 172 (Genetics Lab)
Lab: 3:30-5:30, M, W, TNS 172
Text: Essentials of Genetics, 9th ed., Klug, Cummings, Spencer, and Palladino.

COURSE OVERVIEW



Welcome to Genetics! More than any other subdiscipline, genetics is truly fundamental to all of biology. At a biochemical level, genes are the recipes for the proteins made by the cell, which will determine a cell's structure and function. A major part of cell division is dividing the DNA correctly into two daughter cells, which in turn will divide to produce a multicellular organism. Sexual reproduction, at a cellular level, is the joining of two sets of genes, making a new genetic recipe. At the organismal level, changes in gene regulation cause differences in cell, tissue, and organ function, and cause changes in development through an organism's lifetime. Finally, changes in genetic structure are how populations evolve. So, from the cellular level to the organismal level to the populational level, genetics is fundamental to all of biology. We will examine each of these levels in detail through this course. So, whether you are interested in molecular biology, physiology, or ecology and evolution, this course should be relevant and interesting to you.

LECTURE SYLLABUS

DATE TOPIC (and study questions) PPT READINGS
LAB

July 10 (T)
July 12 (W)
July 13 (TH)

Darwin, Mendel, and Modern Biology
Mechanisms of Inheritance
Modifications to Mendelian Patterns
ppt
ppt
ppt
1, 3
2, 6
4, 464-473
safety video, Drosophila
Mendel's Peas
.
July 17 (M)
July 19 (W)
July 20 (TH)
Sex Determination and Sex Linkage
Linkage, Mapping, and Bacterial Genetics
DNA and Chromosome Structure
ppt
ppt
ppt
5
7, 8
9, 11
EXAM #1
Bacterial Transformation
.
July 24 (M)
July 26 (W)
July 27 (TH)
EXAM #2
DNA Replication
Protein Synthesis
.
ppt
ppt
.
10
12, 13
Flies: F1 Data and Back Cross
Movie: The Double Helix
.
July 31 (M)
Aug 2 (W)
Aug 3 (TH)
Regulation of Gene Expression and Development
Mutation and Cancer
Recombinant DNA Technology
ppt
ppt
ppt
15, 20
14, 16
17, 19
EXAM #3
DNA Fingerprinting
.
Aug 7 (M)
Aug 9 (W)
Aug 10 (TH)
Bioinformatics and Population Genetics
Evolutionary and Population Genetics
FINAL EXAM
ppt
ppt
.
18
22
.
F2 Data, Bioinformatics Problem
Population Gen Problems and Phylogenies
.

ATTENDANCE AND GRADING POLICY

The university's policy, which I will employ in BIO221, is as follows:
"Instructors are expected to establish and announce attendance requirements for their courses. Unless an instructor announces otherwise, the following guidelines are assumed to be in effect: Freshman will be withdrawn from a course if absent, for any reason, 15 percent of the class meetings (No more than 2 for this class). Other students will be withrawn from a course if absent 25 percent of the class meetings (no more than 4 for this class). In both cases, a failing grade (F) will be recorded unless the absences were due to providential reasons, in which case a grade of W may be assigned after consultation with the Associate Academic Dean" (University Catalog).

Attendance at lab is mandatory.
If you have a disability and you need academic accomodations, you should contact the Office of Accessibility Services. Do this IN THE FIRST WEEK, before the first exam.


Grading Policy:
I will assign grades in the following manner. There are 700 available points, and letter grades will be assigned such that grades of 90% or above earn at least an "A range" grade, 80%-89% at least a "B range" grade, and so forth. Determination of these letter grade cutoffs will be at the sole discretion of the professor; "curving", if warranted, will be on total points accumulated and not individual assignments. +/- grades will be assigned based on total percentage of points earned, with some subjective modification possible if there is signifiacnt improvement on the final exam.


ASSIGNMENT POINTS
Exams, 3@ 100 each 300
Lab Exercises (6) 200
Final Exam (comprehensive) 200
TOTAL 700