Eukaryotic DNA Synthesis (cont.)

• Semidiscontinuous Replication

  • Multiple origins

• DNA synthesis at the ends of chromosomes

  • leading strand continues to the end
  • lagging strand has inadequate template

• Elizabeth Blackburn & Carol Greider

  • Tetrahymena (ciliated protozoan)
  • Telomerase: protein with an RNA template
    • exact sequence is species specific
    • Humans: TTAGGG/AATCCC

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