Catalytic Activities of Many Enzymes Are Regulated

• Metabolism: groups of enzymes work together in sequential chains

• At least one enzyme (pacemaker) that sets the rate

• Often first enzyme of sequence is pacemaker

• Regulatory enzymes: activity modulated through various types of molecular signals

  • Feedback inhibition:
  • Allosteric interaction:
    • Regulatory proteins: either stimulate or inhibit

• Covalent modification:

• Proteolytic activation:

  • Zymogens.

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